Tranditional HPLC method development involves highly skillful, exerienced, knowledgeable, and intuitive operators to generate efficient separation methods. This is often a time-consuming endevor that does not always produce the best possible separation results in spite of the best efforts. Automated method development (AMD) with the Hitachi LaChrom Elite (LCE) HPLC system in conjunction with ChromSword Auto (CSA) provides a unique AMD system that will separate multi-component systems effortlessly, accurately, and with significant savings in both time and costs for the methoddevelopment. (Published in LCGC North America, September 2003.159 KB)