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Chromaster 5610 MS detector is a new mass detector, designed for LC users, and it is different from conventional mass spectrometers. With this detector and a syringe pump, a sample solution is introduced directly to 5610 MS Detector and the mass information can be obtained. This time, the analysis example of chlorhexidine, a main component of antibacterial disinfectants, is introduced here. A protonated mollecular ion could be confirmed by simple operation.