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Highly rated, highly reliable Hitachi HPLC Chromaster series. The ChromAssist Data Station is a “Chromatography Data System (CDS)” for centrally managing Chromaster series modules, and streamlining the entire process from measurement and analysis to reporting. ChromAssist supports high-performance liquid chromatography (HPLC) analysis with a variety of features based on user preferences, and analysis guidance features that incorporate Hitachi’ s many years of knowledge.
Operations can be performed using an intuitive screen with each parameter represented by an image.
Loaded with guidance features and enhanced help features to support the overall analytical workflow, from starting up the device through testing, analysis, maintenance, and troubleshooting. There is no longer a need to refer to a manual. Intuitive tutorials have been prepared for fi¬rst time users.
Recording analytical procedures as routine analyses, making repeated measurements easier. Furthermore, the guidance features include content for different purposes, such as LC and MS basic lectures, maintenance videos, and troubleshooting.
These can be conveniently viewed during the measurement.
To obtain accurate analytical results, it is important to fully ensure device and system performance, including the column. Degradation of the column and variations in detection sensitivity can be easily determined by recording a summary of the theoretical number of plates, the resolution, and the reproducibility (SD, RSD). In addition, by setting RT window for results, assessment comments (Pass/Fail) can be noted, and the stability of the system can be assessed on a daily basis.
Data acquired for each analysis can be checked for quality. System Suitability Test (SST) reports conforming to the Japanese, US, and European Pharmacopeias (JP, USP, and EP) and operation check results that classify the operating conditions for each HPLC module can be summarized in a report.
System suitability test report
This is useful for evaluating the overall analysis system. In addition, degradation of the column and other components can be evaluated by checking the theoretical number of plates each day.
To ensure that each HPLC module is in good condition, it is important to monitor and manage consumable parts. Part replacement dates, usage history (liquid feed amount, number of uses, cumulative time, etc.), and guidelines for recommended replacement can be recorded and checked to monitor the condition of consumables. This information can be output as a report or stored in a log. In addition, when it is time to replace a consumable, the Assist feature provides visual support through maintenance videos.
We have published a collection of specific troubleshooting examples in a guide and we provide support to resolve problems such as abnormal analytical results. These examples reflect the experiences of both Hitachi and Hitachi users collected over many years.
ChromAssist supports Chromaster, ChomasterUltra Rs, LaChrom Elite and LaChrom Ultra series modules which are described below.
L-2100 Pump, L-2130 Pump, L-2200 Autosampler, L-2300 Column Oven, L-2350 Column Oven, L-2400 UV Detector, L-2420 UV-VIS Detector, L-2455 Diode Array Detector, L-2480 FL Detector, L-2485 FL Detector, L-2490 RI Detector, AID and Organizer.
L-2160U Pump, L-2200U Autosampler, L-2300 Column Oven, L-2350 Column Oven, L-2420 UV-VIS Detector, L-2455U Diode Array Detector and L-2485U FL Detector.
Please refer to the following specification.
|ChromAssist Data Station|
|Module control||System series name||Chromaster, ChromasterUltra Rs, LaChrom Elite, LaChrom Ultra *1|
|Number of systems||Maximum of 2 systems (however, up to 1 MS Detector)|
|Number of data acquisition channels||10 – 3,200 ms
(L-2400/2420/2455/2480/2485, 5450, AID: 50 – 3200 ms
L-2490: 100 – 3200 ms)
|Analog input||AID (1 ch/board, 2 boards/system, maximum of 2 ch) (however, data collection cycle 50 ms minimum)|
|Supported PC||OS||Windows computer *2|
|Software||DAD control / analysis (standard specification)|
|System suitability test (standard specification)|
|Data analysis features||Integration processing||Peak determination depending on noise and peak sensitivity|
|Configurable integration method such as vertical partitioning, tailing, and integration inhibit|
|Quantitative calculations||Calculation methods: No Calibration(percentage method), Normalized Percent, External Standard,|
|Internal Standard,Standard Addition, Manual|
|Calibration curve order: linear R, linear C, Quadratic and Cubic,|
|Calibration curve weight; 1.0, Conc, 1/Conc, 1/Conc*Conc. Force zero.|
|Multiple point calibration curve: maximum 20 points|
|Data diagnosis||Diagnostic peak area/height, expected concentration peaks|
|System suitability test||Theoretical number of plates, Resolution, Asymmetry(5%), Asymmetry(10%), Signal to Noise, Retention time(Standard deviation), Area(Relative standard deviation), Height(Relative standard deviation)|
|Statistical calculation features||Calculation items||Retention time, Area/Height|
|Results||Average, SD, RSD|
|DAD acquisition / analysis features||Extraction chromatography||4 wavelengths fixed chromatogram, Best wavelength chromatogram|
|Peak purity check||Enable (Peak height percentage for side spectra (upslope point and downslope point) )|
|Library search||Enable (Spectral library search, Reverse library search)|
|Mass acquisition / analysis features||Mass chromatogram extraction||Possible (Extract designation m/z from scan data, Extract from TIC and scan data acquisition)|
|Report||Layout||Can be created with Report Layout Editor|
|Other||Output as Microsoft Excel file *3|
|Export||Data conversion||CSV files|
|Graphical image export file formats (PNG, BMP, TIFF, Enhanced Meta File)|
|Other||Part 11 support function||FDA 21 CFR Part 11 support function installed|