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MirrorCLEM, a simple solution for correlative light and electron microscopy (CLEM).
MirrorCLEM is designed to simplify the correlation of specimens between optical and electron microscopes. With this novel system, specimens can be observed under any optical microscope to obtain light/fluorescent image information and then be easily coordinated to our SEM stage whereby high-resolution EM data can be acquired at the same location. This correlation technique utilizes the optical image(s) as an anchor map thereby automatically driving the SEM stage to desired locations by simply clicking on a region of interest (ROI). Additionally, MirrorCLEM is capable of displaying a real-time overlay of the optical and EM images for efficient and high precision data acquisition.